Values of coagulation parameters in hospitalized patients with SARS-CoV-2 infection in the University Clinical Hospital Mostar

Abstract

Background: The aim of this study was to determine the presence of coagulation parameter disorders in patients hospitalized due to COVID-19 and to investigate the relationship between the abnormalities of coagulation parameters and the final outcome.

Methods: We performed a retrospective cohort study of 81 patients admitted to the University Clinical Hospital Mostar, due to respiratory infection by SARS-CoV-2, in the period from March 15th to May 15th, 2021. Subjects were divided into two groups according to the final outcome. We analyzed age, sex, comorbidity frequency and parameters of coagulation function.

Main findings: Of the 81 patients, 42 died and 72.7% died in the Respiratory Center (p<0.001). Two-thirds of the respondents were male. The mean age of all respondents was 72.88±14.21 years. Non-survivors were significantly older than survivors (p=0.002). Previous chronic disease was confirmed in 84% of the subjects and the most common comorbidity was arterial hypertension. D-dimers were elevated in 95% of the subjects. Non-survivors had a statistically significant prolongation of APTT in seconds (p=0.005) than survivors, while in other coagulation parameters, there was no statistical significance with respect to the severity of the clinical status and the final outcome.

Principal conclusions: SARS-CoV-2 infection is associated with abnormalities in the parameters of coagulation function. Moreover, APTT is an important factor for prognosis assessment in patients with COVID-19