Efficacy and Safety of Xylometazoline-Based Nasal Sprays with and Without Lysozyme in the Treatment of Acute Nasopharyngitis

Lysozyme in treatment of nasopharyngitis

Authors

  • Zumreta Pintol Public Institution Sarajevo Canton Health Center, Sarajevo, Bosnia and Herzegovina
  • Zorica Pušara Specialist center "Nine doctors" Banja Luka, Bosnia and Herzegovina
  • Suad Imamović The Public Institution Health Center of Živinice, Živinice, Bosnia and Herzegovina
  • Đenad Hodžić Cantonal Hospital Zenica, Zenica, Bosnia and Herzegovina
  • Amira Skopljak
  • Aziz Šukalo
  • Meliha Mehić
  • Amna Tanović Avdić
  • Lejla Kurtalić
  • Sanja Trhulj
  • Merita Tirić Čampara
  • Una Glamočlija Bosnalijek d.d.

Keywords:

nasopharyngitis, nasal obstruction, lysozyme, xylometazoline, nasal sprays

Abstract

Background: Acute nasopharyngitis is a common condition usually accompanied by nasal congestion. The aim of this study was to compare efficacy and safety of a spray containing xylometazoline and lysozyme with a spray containing only xylometazoline in the treatment of acute nasopharyngitis.

Methods: A prospective, comparative, post-marketing study was performed on subjects with acute nasopharyngitis divided into xylometazoline+lysozyme or xylometazoline nasal spray groups. Data collection was performed at baseline before treatment, 30 minutes after treatment and at seven-day follow-up.

Main findings: Out of 173 included subjects, 59 were in the xylometazoline+lysozyme and 114 in the xylometazoline group. In both groups nasal patency was significantly improved 30 minutes after the therapy application (p<0.001). In the xylometazoline+lysozyme group, all subjects had nasal decongestion within 20 minutes and this was significantly quicker (p=0.037) than the xylometazoline group, where 16 subjects (14%) needed 20 to 120 minutes for nasal decongestion. All adverse events were mild and there was no significant difference in the number of adverse events between the groups.

Principal conclusions: Nasal sprays containing xylometazoline with or without lysozyme were effective and safe in the treatment of acute nasopharyngitis. The spray containing xylometazoline with lysozyme showed a faster effect with significantly shorter time to nasal decongestion. All recorded adverse events were mild and there was no difference between the groups in the number of recorded adverse events.

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Published

2023-12-28

How to Cite

1.
Pintol Z, Pušara Z, Imamović S, Hodžić Đenad, Skopljak A, Šukalo A, et al. Efficacy and Safety of Xylometazoline-Based Nasal Sprays with and Without Lysozyme in the Treatment of Acute Nasopharyngitis: Lysozyme in treatment of nasopharyngitis. ABCR [Internet]. 2023 Dec. 28 [cited 2024 Apr. 19];2(2):119-25. Available from: http://abcr-mefmo.org/index.php/abcr/article/view/37

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