Efficacy and Safety of Xylometazoline-Based Nasal Sprays with and Without Lysozyme in the Treatment of Acute Nasopharyngitis

Lysozyme in treatment of nasopharyngitis


  • Zumreta Pintol Public Institution Sarajevo Canton Health Center, Sarajevo, Bosnia and Herzegovina
  • Zorica Pušara Specialist center "Nine doctors" Banja Luka, Bosnia and Herzegovina
  • Suad Imamović The Public Institution Health Center of Živinice, Živinice, Bosnia and Herzegovina
  • Đenad Hodžić Cantonal Hospital Zenica, Zenica, Bosnia and Herzegovina
  • Amira Skopljak
  • Aziz Šukalo
  • Meliha Mehić
  • Amna Tanović Avdić
  • Lejla Kurtalić
  • Sanja Trhulj
  • Merita Tirić Čampara
  • Una Glamočlija Bosnalijek d.d.


nasopharyngitis, nasal obstruction, lysozyme, xylometazoline, nasal sprays


Background: Acute nasopharyngitis is a common condition usually accompanied by nasal congestion. The aim of this study was to compare efficacy and safety of a spray containing xylometazoline and lysozyme with a spray containing only xylometazoline in the treatment of acute nasopharyngitis.

Methods: A prospective, comparative, post-marketing study was performed on subjects with acute nasopharyngitis divided into xylometazoline+lysozyme or xylometazoline nasal spray groups. Data collection was performed at baseline before treatment, 30 minutes after treatment and at seven-day follow-up.

Main findings: Out of 173 included subjects, 59 were in the xylometazoline+lysozyme and 114 in the xylometazoline group. In both groups nasal patency was significantly improved 30 minutes after the therapy application (p<0.001). In the xylometazoline+lysozyme group, all subjects had nasal decongestion within 20 minutes and this was significantly quicker (p=0.037) than the xylometazoline group, where 16 subjects (14%) needed 20 to 120 minutes for nasal decongestion. All adverse events were mild and there was no significant difference in the number of adverse events between the groups.

Principal conclusions: Nasal sprays containing xylometazoline with or without lysozyme were effective and safe in the treatment of acute nasopharyngitis. The spray containing xylometazoline with lysozyme showed a faster effect with significantly shorter time to nasal decongestion. All recorded adverse events were mild and there was no difference between the groups in the number of recorded adverse events.




How to Cite

Pintol Z, Pušara Z, Imamović S, Hodžić Đenad, Skopljak A, Šukalo A, et al. Efficacy and Safety of Xylometazoline-Based Nasal Sprays with and Without Lysozyme in the Treatment of Acute Nasopharyngitis: Lysozyme in treatment of nasopharyngitis. ABCR [Internet]. 2023 Dec. 28 [cited 2024 Apr. 19];2(2):119-25. Available from: http://abcr-mefmo.org/index.php/abcr/article/view/37



Original articles